Modulation of protein–protein interactions by synthetic receptors: Design of molecules that disrupt serine protease–proteinaceous inhibitor interaction

In the present article we describe the design and evaluation of a synthetic receptor that binds to the exterior surface of chymotrypsin and disrupts its interaction with proteinaceous inhibitors, such as soybean trypsin inhibitor, basic pancreatic trypsin inhibitor, ovomucoid turkey inhibitor, and B...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Park, Hyung Soon, Lin, Qing, Hamilton, Andrew D.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2002
Schlagworte:	Physical Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122729/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11959960/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.082675899
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