Intramolecular DNA coiling mediated by metallo-supramolecular cylinders: Differential binding of P and M helical enantiomers

We have designed a synthetic tetracationic metallo-supramolecular cylinder that targets the major groove of DNA with a binding constant in excess of 10(7) M(−1) and induces DNA bending and intramolecular coiling. The two enantiomers of the helical molecule bind differently to DNA and have different...

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Detalhes bibliográficos
Main Authors: Meistermann, Isabelle, Moreno, Virtudes, Prieto, Maria J., Moldrheim, Erlend, Sletten, Einar, Khalid, Syma, Rodger, P. Mark, Peberdy, Jemma C., Isaac, Christian J., Rodger, Alison, Hannon, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2002
Assuntos:
Physical Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC122723/
https://ncbi.nlm.nih.gov/pubmed/11959957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.062634499
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