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Testosterone attenuates expression of vascular cell adhesion molecule-1 by conversion to estradiol by aromatase in endothelial cells: Implications in atherosclerosis
We previously reported that testosterone attenuated atherogenesis in LDLR(−/−) male mice, and that this effect of testosterone was most likely caused by its conversion to estradiol. Estradiol inhibits vascular cell adhesion molecule-1 (VCAM-1) expression, and expression of VCAM-1 is one of the early...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The National Academy of Sciences
2002
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC122647/ https://ncbi.nlm.nih.gov/pubmed/11904449 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.052703199 |
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