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Disruption of estrogen receptor β gene impairs spatial learning in female mice

Here we provide the first evidence, to our knowledge, that estradiol (E(2)) affects learning and memory via the newly discovered estrogen receptor β (ERβ). In this study, ERβ knockout (ERβKO) and wild-type littermates were tested for spatial learning in the Morris water maze after ovariectomy, appro...

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Detalles Bibliográficos
Main Authors: Rissman, Emilie F., Heck, Amy L., Leonard, Julie E., Shupnik, Margaret A., Gustafsson, Jan-Åke
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 2002
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC122637/
https://ncbi.nlm.nih.gov/pubmed/11891272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.012032699
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