A Major Locus for Fasting Insulin Concentrations and Insulin Resistance on Chromosome 6q with Strong Pleiotropic Effects on Obesity-Related Phenotypes in Nondiabetic Mexican Americans

Insulin resistance and hyperinsulinemia are strong correlates of obesity and type 2 diabetes, but little is known about their genetic determinants. Using data on nondiabetics from Mexican American families and a multipoint linkage approach, we scanned the genome and identified a major locus near mar...

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Autori principali: Duggirala, Ravindranath, Blangero, John, Almasy, Laura, Arya, Rector, Dyer, Thomas D., Williams, Kenneth L., Leach, Robin J., O’Connell, Peter, Stern, Michael P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society of Human Genetics 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1226096/
https://ncbi.nlm.nih.gov/pubmed/11283790
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