Quantitative measurement of translesion replication in human cells: Evidence for bypass of abasic sites by a replicative DNA polymerase

Mutations in oncogenes and tumor suppressor genes are critical in the development of cancer. A major pathway for the formation of mutations is the replication of unrepaired DNA lesions. To better understand the mechanism of translesion replication (TLR) in mammals, a quantitative assay for TLR in cu...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Avkin, Sharon, Adar, Sheera, Blander, Gil, Livneh, Zvi
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2002
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122598/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11891323/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.062038699
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