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The embryonic stem cell transcription factors Oct-4 and FoxD3 interact to regulate endodermal-specific promoter expression

The POU homeodomain protein Oct-4 and the Forkhead Box protein FoxD3 (previously Genesis) are transcriptional regulators expressed in embryonic stem cells. Down-regulation of Oct-4 during gastrulation is essential for proper endoderm development. After gastrulation, FoxD3 is generally down-regulated...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Guo, Ying, Costa, Robert, Ramsey, Heather, Starnes, Trevor, Vance, Gail, Robertson, Kent, Kelley, Mark, Reinbold, Rolland, Scholer, Hans, Hromas, Robert
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122580/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11891324/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.062041099
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