Abnormal accumulation of hyaluronan matrix diminishes contact inhibition of cell growth and promotes cell migration

Elevated hyaluronan biosynthesis and matrix deposition correlates with cell proliferation and migration. We ectopically expressed three isoforms of hyaluronan synthase (HAS1, HAS2, or HAS3) in nontransformed rat 3Y1 cells and observed a de novo, massive formation of a hyaluronan matrix that resulted...

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Autori principali: Itano, Naoki, Atsumi, Fukiko, Sawai, Takahiro, Yamada, Yoichi, Miyaishi, Osamu, Senga, Takeshi, Hamaguchi, Michinari, Kimata, Koji
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2002
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC122571/
https://ncbi.nlm.nih.gov/pubmed/11891291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.052026799
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