Abnormal accumulation of hyaluronan matrix diminishes contact inhibition of cell growth and promotes cell migration

Elevated hyaluronan biosynthesis and matrix deposition correlates with cell proliferation and migration. We ectopically expressed three isoforms of hyaluronan synthase (HAS1, HAS2, or HAS3) in nontransformed rat 3Y1 cells and observed a de novo, massive formation of a hyaluronan matrix that resulted...

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Detalhes bibliográficos
Main Authors: Itano, Naoki, Atsumi, Fukiko, Sawai, Takahiro, Yamada, Yoichi, Miyaishi, Osamu, Senga, Takeshi, Hamaguchi, Michinari, Kimata, Koji
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC122571/
https://ncbi.nlm.nih.gov/pubmed/11891291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.052026799
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