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Target-induced formation of neuraminidase inhibitors from in vitro virtual combinatorial libraries
Neuraminidase, a key enzyme responsible for influenza virus propagation, has been used as a template for selective synthesis of small subsets of its own inhibitors from theoretically highly diverse dynamic combinatorial libraries. We show that the library building blocks, aldehydes and amines, form...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC122532/ https://ncbi.nlm.nih.gov/pubmed/11891312 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.052703799 |
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