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Poly(ADP-ribose) polymerase-1 dependence of stress-induced transcription factors and associated gene expression in glia
Poly(ADP-ribose) polymerase-1 (PARP-1, EC 2.4.2.30), a nuclear enzyme activated by DNA strand breaks, physiologically participates in DNA repair. Excessive activation of PARP-1 by cellular insults depletes its substrate β-nicotinamide adenine dinucleotide and ATP, leading to cell death. PARP-1-defic...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The National Academy of Sciences
2002
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC122508/ https://ncbi.nlm.nih.gov/pubmed/11854472 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.052712399 |
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