Drug selection with paclitaxel restores expression of linked IL-2 receptor γ-chain and multidrug resistance (MDR1) transgenes in canine bone marrow

Unstable expression of transferred genes is a major obstacle to successful gene therapy of hematopoietic diseases. We have investigated in a canine large-animal model whether expression of transduced genes can be recovered in vivo. Mixed-breed dogs had undergone autologous bone marrow transplantatio...

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Bibliographische Detailangaben
Hauptverfasser: Licht, Thomas, Haskins, Mark, Henthorn, Paula, Kleiman, Sandra E., Bodine, David M., Whitwam, Todd, Puck, Jennifer M., Gottesman, Michael M., Melniczek, John R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2002
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC122483/
https://ncbi.nlm.nih.gov/pubmed/11867757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.052712199
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