Genomic DNA breakpoints in AML1/RUNX1 and ETO cluster with topoisomerase II DNA cleavage and DNase I hypersensitive sites in t(8;21) leukemia

The translocation t(8;21)(q22;q22) is one of the most frequent chromosome translocations in acute myeloid leukemia (AML). AML1/RUNX1 at 21q22 is involved in t(8;21), t(3;21), and t(16;21) in de novo and therapy-related AML and myelodysplastic syndrome as well as in t(12;21) in childhood B cell acute...

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Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Zhang, Yanming, Strissel, Pamela, Strick, Reiner, Chen, Jianjun, Nucifora, Giuseppina, Le Beau, Michelle M., Larson, Richard A., Rowley, Janet D.
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 2002
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122474/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11867721/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.042702899
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