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Specific Deletion Occurring in the Directed Evolution of 6-Phosphogluconate Dehydrogenase in ESCHERICHIA COLI

A novel genetic change leading to increased activity of 6-phosphogluconate dehydrogenase (6PGD) in E. coli has been observed. The mutation is a deletion of approximately 0.4 kilobase pairs occurring between the structural gene of 6PGD (gnd) and one copy of an insertion element (IS5 ) found normally...

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Autors principals: Miller, Raymond D., Dykhuizen, Daniel E., Green, Louis, Hartl, Daniel L.
Format: Artigo
Idioma:Inglês
Publicat: 1984
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1224263/
https://ncbi.nlm.nih.gov/pubmed/6392014
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