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Biosynthesis of anandamide and N-palmitoylethanolamine by sequential actions of phospholipase A2 and lysophospholipase D.

Anandamide (an endocannabinoid) and other bioactive long-chain NAEs (N-acylethanolamines) are formed by direct release from N-acyl-PE (N-acyl-phosphatidylethanolamine) by a PLD (phospholipase D). However, the possible presence of a two-step pathway from N-acyl-PE has also been suggested previously,...

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Autors principals: Sun, Yong-Xin, Tsuboi, Kazuhito, Okamoto, Yasuo, Tonai, Takeharu, Murakami, Makoto, Kudo, Ichiro, Ueda, Natsuo
Format: Artigo
Idioma:Inglês
Publicat: 2004
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1224205/
https://ncbi.nlm.nih.gov/pubmed/14998370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040031
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