Increased levels of insulin and insulin-like growth factor-1 hybrid receptors and decreased glycosylation of the insulin receptor alpha- and beta-subunits in scrapie-infected neuroblastoma N2a cells.

We have previously shown that ScN2a cells (scrapie-infected neuroblastoma N2a cells) express 2-fold- and 4-fold-increased levels of IR (insulin receptor) and IGF-1R (insulin-like growth factor-1 receptor) respectively. In addition, the IR alpha- and beta-subunits are aberrantly processed, with appar...

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Détails bibliographiques
Auteurs principaux: Nielsen, Daniel, Gyllberg, Hanna, Ostlund, Pernilla, Bergman, Tomas, Bedecs, Katarina
Format: Artigo
Langue:Inglês
Publié: 2004
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1224193/
https://ncbi.nlm.nih.gov/pubmed/15025560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040010
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