Identification and characterization of the conserved nucleoside-binding sites in the Epstein-Barr virus thymidine kinase.

Thymidine kinase (TK), encoded by EBV (Epstein-Barr virus), is an attractive target for antiviral therapy and provides a novel approach to the treatment of EBV-associated malignancies. Despite the extensive use of nucleoside analogues for the treatment of viral infections and cancer, the structure-f...

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Bibliographic Details
Main Authors: Wu, Chung-Chun, Chen, Min-Che, Chang, Ya-Ru, Hsu, Tsuey-Ying, Chen, Jen-Yang
Format: Artigo
Language:Inglês
Published: 2004
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1224098/
https://ncbi.nlm.nih.gov/pubmed/14705959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031832
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