Calcium mobilization and Rac1 activation are required for VCAM-1 (vascular cell adhesion molecule-1) stimulation of NADPH oxidase activity.

VCAM-1 (vascular cell adhesion molecule-1) plays an important role in the regulation of inflammation in atherosclerosis, asthma, inflammatory bowel disease and transplantation. VCAM-1 activates endothelial cell NADPH oxidase, and this oxidase activity is required for VCAM-1-dependent lymphocyte migr...

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Bibliografiske detaljer
Main Authors: Cook-Mills, Joan M, Johnson, Jacob D, Deem, Tracy L, Ochi, Atsuo, Wang, Lei, Zheng, Yi
Format: Artigo
Sprog:Inglês
Udgivet: 2004
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223954/
https://ncbi.nlm.nih.gov/pubmed/14594451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20030794
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