The growth hormone receptor interacts with its sheddase, the tumour necrosis factor-alpha-converting enzyme (TACE).

Proteolysis of the GHR (growth hormone receptor) occurs at the cell surface and results in the release of its extracellular domain, the GHBP (growth hormone-binding protein). TACE (tumour necrosis factor-alpha-converting enzyme) has been identified as a putative protease responsible for GHR cleavage...

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Bibliographic Details
Main Authors: Schantl, Julia A, Roza, Marcel, Van Kerkhof, Peter, Strous, Ger J
Format: Artigo
Language:Inglês
Published: 2004
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223864/
https://ncbi.nlm.nih.gov/pubmed/14519102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031321
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