L-alanine-glyoxylate aminotransferase II of rat kidney and liver mitochondria possesses cysteine S-conjugate beta-lyase activity: a contributing factor to the nephrotoxicity/hepatotoxicity of halogenated alkenes?

Several halogenated alkenes are metabolized in part to cysteine S-conjugates, which are mitochondrial toxicants of kidney and, to a lesser extent, other organs. Toxicity is due to cysteine S-conjugate beta-lyases, which convert the cysteine S-conjugate into pyruvate, ammonia and a reactive sulphur-c...

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Hauptverfasser: Cooper, Arthur J L, Krasnikov, Boris F, Okuno, Etsuo, Jeitner, Thomas M
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2003
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223738/
https://ncbi.nlm.nih.gov/pubmed/12859250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20030988
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