Role of flanking sequences and phosphorylation in the recognition of the simian-virus-40 large T-antigen nuclear localization sequences by importin-alpha.

The nuclear import of simian-virus-40 large T-antigen (tumour antigen) is enhanced via phosphorylation by the protein kinase CK2 at Ser112 in the vicinity of the NLS (nuclear localization sequence). To determine the structural basis of the effect of the sequences flanking the basic cluster KKKRK, an...

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Hlavní autoři: Fontes, Marcos R M, Teh, Trazel, Toth, Gabor, John, Anna, Pavo, Imre, Jans, David A, Kobe, Bostjan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2003
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223685/
https://ncbi.nlm.nih.gov/pubmed/12852786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20030510
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