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Polyamines reverse non-steroidal anti-inflammatory drug-induced toxicity in human colorectal cancer cells.
Naproxen, sulindac and salicylate, three NSAIDs (non-steroidal anti-inflammatory drugs), were cytotoxic to human colorectal cancer cells in culture. Toxicity was accompanied by significant depletion of intracellular polyamine content. Inhibition of ornithine decarboxylase (the first enzyme of the po...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1223611/ https://ncbi.nlm.nih.gov/pubmed/12793857 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20030280 |
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