Biochemical characterization of the active heterodimer form of human heparanase (Hpa1) protein expressed in insect cells.

The mammalian endoglycosidase heparanase (Hpa1) is primarily responsible for cleaving heparan sulphate proteoglycans (HSPGs) present on the basement membrane of cells and its potential for remodelling the extracellular matrix (ECM) could be important in embryonic development and tumour metastasis. E...

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Detalhes bibliográficos
Main Authors: McKenzie, Edward, Young, Kathryn, Hircock, Margaret, Bennett, James, Bhaman, Maina, Felix, Robert, Turner, Paul, Stamps, Alasdair, McMillan, David, Saville, Giles, Ng, Stanley, Mason, Sean, Snell, Daniel, Schofield, Darren, Gong, Haiping, Townsend, Reid, Gallagher, John, Page, Martin, Parekh, Raj, Stubberfield, Colin
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223510/
https://ncbi.nlm.nih.gov/pubmed/12713442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20030318
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