Structural studies on the reaction of isopenicillin N synthase with the substrate analogue delta-(l-alpha-aminoadipoyl)-l-cysteinyl-d-alpha-aminobutyrate.

Isopenicillin N synthase (IPNS) is a non-haem iron(II) oxidase which catalyses the biosynthesis of isopenicillin N from the tripeptide delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-valine (ACV). Herein we report crystallographic studies to investigate the reaction of IPNS with the truncated substrate a...

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Detalhes bibliográficos
Main Authors: Long, Alexandra J, Clifton, Ian J, Roach, Peter L, Baldwin, Jack E, Schofield, Christopher J, Rutledge, Peter J
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223433/
https://ncbi.nlm.nih.gov/pubmed/12622704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20021627
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