The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation.

Fn14 is a growth-factor-inducible immediate-early-response gene encoding a 102-amino-acid type I transmembrane protein. The human Fn14 protein was recently identified as a cell-surface receptor for the tumour necrosis factor (TNF) superfamily member named TWEAK (TNF-like weak inducer of apoptosis)....

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Detalhes bibliográficos
Main Authors: Brown, Sharron A N, Richards, Christine M, Hanscom, Heather N, Feng, Sheau-Line Y, Winkles, Jeffrey A
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223299/
https://ncbi.nlm.nih.gov/pubmed/12529173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20021730
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