Targeting endothelium and its dynamic caveolae for tissue-specific transcytosis in vivo: A pathway to overcome cell barriers to drug and gene delivery

Site-directed pharmacodelivery is a desirable but elusive goal. Endothelium and epithelium create formidable barriers to endogenous molecules as well as targeted therapies in vivo. Caveolae provide a possible, yet unproven, transcellular pathway to overcome such barriers. By using an antibody- and s...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	McIntosh, Deirdre P., Tan, Xiang-Yang, Oh, Phil, Schnitzer, Jan E.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2002
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122308/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11854497/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.251662398
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