A lysophosphatidic acid analogue is revealed as a potent inhibitor of phosphatidylcholine synthesis, inducing apoptosis.

A previous study demonstrated that cross-desensitization experiments performed with the lysophosphatidic acid (LPA) analogues (R)- and (S)-N-palmitoyl-norleucinol 1-phosphate (PNPAs) inhibited LPA-induced platelet aggregation without any stereospecificity. Here we report opposite biological effects...

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Detalhes bibliográficos
Main Authors: Gueguen, Geneviéve, Granci, Virginie, Rogalle, Pierre, Briand-Mésange, Fabienne, Wilson, Michéle, Klaébé, Alain, Tercé, François, Chap, Hugues, Salles, Jean-Pierre, Simon, Marie-Françoise, Gaits, Frédérique
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223009/
https://ncbi.nlm.nih.gov/pubmed/12197836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20020273
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