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A method for optimizing potential-energy functions by a hierarchical design of the potential-energy landscape: Application to the UNRES force field

A method for optimizing potential-energy functions of proteins is proposed. The method assumes a hierarchical structure of the energy landscape, which means that the energy decreases as the number of native-like elements in a structure increases, being lowest for structures from the native family an...

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書誌詳細
主要な著者: Liwo, Adam, Arłukowicz, Piotr, Czaplewski, Cezary, Ołdziej, Stanisław, Pillardy, Jarosław, Scheraga, Harold A.
フォーマット: Artigo
言語:Inglês
出版事項: The National Academy of Sciences 2002
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC122298/
https://ncbi.nlm.nih.gov/pubmed/11854494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.032675399
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