A method for optimizing potential-energy functions by a hierarchical design of the potential-energy landscape: Application to the UNRES force field

A method for optimizing potential-energy functions of proteins is proposed. The method assumes a hierarchical structure of the energy landscape, which means that the energy decreases as the number of native-like elements in a structure increases, being lowest for structures from the native family an...

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Podrobná bibliografie

Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Liwo, Adam, Arłukowicz, Piotr, Czaplewski, Cezary, Ołdziej, Stanisław, Pillardy, Jarosław, Scheraga, Harold A.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 2002
Témata:	Biological Sciences
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122298/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11854494/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.032675399
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