Novel peptide inhibitors of Leishmania gp63 based on the cleavage site of MARCKS (myristoylated alanine-rich C kinase substrate)-related protein.

The zinc metalloprotease gp63 (leishmanolysin; promastigote surface protease) is expressed at high density at the surface of Leishmania promastigotes. Efficient non-toxic inhibitors of gp63 do not exist, and its precise role in parasite physiology remains unknown. MARCKS (myristoylated alanine-rich...

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Detalhes bibliográficos
Main Authors: Corradin, Sally, Ransijn, Adriana, Corradin, Giampietro, Bouvier, Jacques, Delgado, Maria Belen, Fernandez-Carneado, Jimena, Mottram, Jeremy C, Vergères, Guy, Mauël, Jacques
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222923/
https://ncbi.nlm.nih.gov/pubmed/12137567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20020386
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