Genistein inhibits CCAAT/enhancer-binding protein beta (C/EBPbeta) activity and 3T3-L1 adipogenesis by increasing C/EBP homologous protein expression.

The tyrosine kinase inhibitor genistein inhibits 3T3-L1 adipogenesis when present during the first 72 h of differentiation. In this report, we investigated the underlying mechanisms involved in the anti-adipogenic effects of genistein. We found that genistein blocked the DNA binding and transcriptio...

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Autori principali: Harmon, Anne W, Patel, Yashomati M, Harp, Joyce B
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2002
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222872/
https://ncbi.nlm.nih.gov/pubmed/12095417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20020300
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