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Induction of apoptosis in human leukaemic cells by IPENSpm, a novel polyamine analogue and anti-metabolite.

Human promyelogenous leukaemic cells (HL-60) were treated with novel spermine analogue, ( S )- N (1)-(2-methyl-1-butyl)- N (11)-ethyl-4,8-diazaundecane (IPENSpm), and the effects on growth and intracellular polyamine metabolism were measured. IPENSpm was cytotoxic to these cells at concentrations gr...

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Detalhes bibliográficos
Main Authors: Fraser, Alison V, Woster, Patrick M, Wallace, Heather M
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222862/
https://ncbi.nlm.nih.gov/pubmed/12086584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20020156
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