Stopped-flow kinetic studies of electron transfer in the reductase domain of neuronal nitric oxide synthase: re-evaluation of the kinetic mechanism reveals new enzyme intermediates and variation with cytochrome P450 reductase.

The reduction by NADPH of the FAD and FMN redox centres in the isolated flavin reductase domain of calmodulin-bound rat neuronal nitric oxide synthase (nNOS) has been studied by anaerobic stopped-flow spectroscopy using absorption and fluorescence detection. We show by global analysis of time-depend...

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Main Authors: Knight, Kirsty, Scrutton, Nigel S
Formato: Artigo
Idioma:Inglês
Publicado: 2002
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222855/
https://ncbi.nlm.nih.gov/pubmed/12079493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20020667
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