Fibroblast growth factor-2 binds to small heparin-derived oligosaccharides and stimulates a sustained phosphorylation of p42/44 mitogen-activated protein kinase and proliferation of rat mammary fibroblasts.

We examine the relationship between the chain length of heparin-derived oligosaccharides, fibroblast growth factor (FGF)-2 binding kinetics and the ability of the oligosaccharides to allow FGF-2-induced proliferation of chlorate-treated rat mammary fibroblasts. First, using an optical biosensor, we...

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Detalhes bibliográficos
Main Authors: Delehedde, Maryse, Lyon, Malcolm, Gallagher, John T, Rudland, Philip S, Fernig, David G
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222755/
https://ncbi.nlm.nih.gov/pubmed/12000311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20011718
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