Opposing roles of serine/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cells.

T-cell activation requires signals from both the T-cell receptor (TcR) and other co-stimulatory molecules such as CD28. TcR- and CD28-mediated signals are integrated during T-cell activation resulting in the expression of cytokine genes such as interleukin-2 (IL-2). An enhancer element (CD28RE) of t...

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Main Authors: Tao, Li, Wadsworth, Scott, Mercer, Jason, Mueller, Cynthia, Lynn, Kirsten, Siekierka, John, August, Avery
Format: Artigo
Jezik:Inglês
Izdano: 2002
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222464/
https://ncbi.nlm.nih.gov/pubmed/11903060
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