Complete beta-oxidation of valproate: cleavage of 3-oxovalproyl-CoA by a mitochondrial 3-oxoacyl-CoA thiolase.

The beta-oxidation of valproic acid (VPA; 2-n-propylpentanoic acid) was investigated in vitro in intact rat liver mitochondria incubated with (3)H-labelled VPA. The metabolism of [4,5-(3)H(2)]VPA and [2-(3)H]VPA was studied by analysing the different acyl-CoA intermediates formed by reverse-phase HP...

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Detalhes bibliográficos
Main Authors: Silva, Margarida F B, Ruiter, Jos P N, Overmars, Henk, Bootsma, Albert H, van Gennip, Albert H, Jakobs, Cornelis, Duran, Marinus, Tavares de Almeida, Isabel, Wanders, Ronald J A
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222442/
https://ncbi.nlm.nih.gov/pubmed/11879205
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