Decorin suppresses transforming growth factor-beta-induced expression of plasminogen activator inhibitor-1 in human mesangial cells through a mechanism that involves Ca2+-dependent phosphorylation of Smad2 at serine-240.

Transforming growth factor-beta (TGFbeta) is a key mediator of extracellular matrix (ECM) accumulation in sclerotic kidney diseases such as diabetic nephropathy. One of the main target cells for TGFbeta in the kidney are glomerular mesangial cells, which respond by increasing expression of ECM prote...

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Библиографические подробности
Главные авторы: Abdel-Wahab, Nadia, Wicks, Stephen J, Mason, Roger M, Chantry, Andrew
Формат: Artigo
Язык:Inglês
Опубликовано: 2002
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222428/
https://ncbi.nlm.nih.gov/pubmed/11879191
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