Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS)

Transgenic overexpression of Cu(+2)/Zn(+2) superoxide dismutase 1 (SOD1) harboring an amyotrophic lateral sclerosis (ALS)-linked familial genetic mutation (SOD1(G93A)) in a Sprague–Dawley rat results in ALS-like motor neuron disease. Motor neuron disease in these rats depended on high levels of muta...

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Detalhes bibliográficos
Main Authors: Howland, David S., Liu, Jian, She, Yijin, Goad, Beth, Maragakis, Nicholas J., Kim, Benjamin, Erickson, Jamie, Kulik, John, DeVito, Lisa, Psaltis, George, DeGennaro, Louis J., Cleveland, Don W., Rothstein, Jeffrey D.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC122237/
https://ncbi.nlm.nih.gov/pubmed/11818550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.032539299
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