Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS)

Transgenic overexpression of Cu(+2)/Zn(+2) superoxide dismutase 1 (SOD1) harboring an amyotrophic lateral sclerosis (ALS)-linked familial genetic mutation (SOD1(G93A)) in a Sprague–Dawley rat results in ALS-like motor neuron disease. Motor neuron disease in these rats depended on high levels of muta...

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Detalles Bibliográficos
Autores principales: Howland, David S., Liu, Jian, She, Yijin, Goad, Beth, Maragakis, Nicholas J., Kim, Benjamin, Erickson, Jamie, Kulik, John, DeVito, Lisa, Psaltis, George, DeGennaro, Louis J., Cleveland, Don W., Rothstein, Jeffrey D.
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 2002
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC122237/
https://ncbi.nlm.nih.gov/pubmed/11818550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.032539299
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