Hydrogen peroxide-induced production of a 40 kDa immunoreactive thyroglobulin fragment in human thyroid cells: the onset of thyroid autoimmunity?

We recently reported that, during in vitro thyroid-hormone synthesis, H(2)O(2) stress cleaved thyroglobulin (Tg) into C-terminal peptides. These peptides were found to contain the immunodominant region of Tg recognized by Tg autoantibodies from patients with an autoimmune thyroid disease. To test th...

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Hlavní autoři: Duthoit, C, Estienne, V, Giraud, A, Durand-Gorde, J M, Rasmussen, A K, Feldt-Rasmussen, U, Carayon, P, Ruf, J
Médium: Artigo
Jazyk:Inglês
Vydáno: 2001
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222257/
https://ncbi.nlm.nih.gov/pubmed/11736644
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