Functional p53 chimeras containing the Epstein–Barr virus Gly-Ala repeat are protected from Mdm2- and HPV-E6-induced proteolysis

Functional inactivation of the tumor suppressor protein p53 by accelerated ubiquitin/proteasome-dependent proteolysis is a common event in tumor progression. Proteasomal degradation is inhibited by the Gly-Ala repeat (GAr) of the Epstein–Barr virus nuclear antigen-1, which acts as a transferable ele...

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Bibliografiska uppgifter
Huvudupphovsmän: Heessen, Stijn, Leonchiks, Ainars, Issaeva, Natalia, Sharipo, Anatoly, Selivanova, Galina, Masucci, Maria G., Dantuma, Nico P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The National Academy of Sciences 2002
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC122225/
https://ncbi.nlm.nih.gov/pubmed/11805282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.022306499
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