Concurrent overexpression of ornithine decarboxylase and spermidine/spermine N(1)-acetyltransferase further accelerates the catabolism of hepatic polyamines in transgenic mice.

We have generated a hybrid transgenic mouse line overexpressing both ornithine decarboxylase (ODC) and spermidine/spermine N(1)-acetyltransferase (SSAT) under the control of the mouse metallothionein (MT) I promoter. In comparison with singly transgenic animals overexpressing SSAT, the doubly transg...

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Detalhes bibliográficos
Main Authors: Suppola, S, Heikkinen, S, Parkkinen, J J, Uusi-Oukari, M, Korhonen, V P, Keinänen, T, Alhonen, L, Jänne, J
Formato: Artigo
Idioma:Inglês
Publicado em: 2001
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222066/
https://ncbi.nlm.nih.gov/pubmed/11513732
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