Polyamine analogues inhibit the ubiquitination of spermidine/spermine N1-acetyltransferase and prevent its targeting to the proteasome for degradation.

Spermidine/spermine N(1)-acetyltransferase (SSAT), a key enzyme in mammalian polyamine catabolism, undergoes rapid turnover (half-life approx. 30 min) and is highly inducible in response to polyamine analogues such as bis(ethyl)spermine (BE-3-4-3), which greatly stabilize the enzyme. Rapid degradati...

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Hlavní autoři: Coleman, C S, Pegg, A E
Médium: Artigo
Jazyk:Inglês
Vydáno: 2001
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222041/
https://ncbi.nlm.nih.gov/pubmed/11485561
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