Up-regulation of steroid sulphatase activity in HL60 promyelocytic cells by retinoids and 1alpha,25-dihydroxyvitamin D3.

HL60 promyeloid cells express both classes of oestrogen receptor (ERalpha and ERbeta). We show that hydrolysis of oestrone sulphate by steroid sulphatase is a major source of oestrone in HL60 cells, and that most of the released oestrone is not metabolized further to 17beta-oestradiol. Treatment of...

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Autori principali: Hughes, P J, Twist, L E, Durham, J, Choudhry, M A, Drayson, M, Chandraratna, R, Michell, R H, Kirk, C J, Brown, G
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2001
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1221747/
https://ncbi.nlm.nih.gov/pubmed/11284723
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