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Proinsulin C-peptide rapidly stimulates mitogen-activated protein kinases in Swiss 3T3 fibroblasts: requirement of protein kinase C, phosphoinositide 3-kinase and pertussis toxin-sensitive G-protein.

It has been demonstrated that proinsulin C-peptide possesses several biological activities and that its specific binding sites are present on the surface of cell membranes. However, the molecular and cellular mechanisms of C-peptide actions are poorly known. In the present study we examined the poss...

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Autori principali: Kitamura, T, Kimura, K, Jung, B D, Makondo, K, Okamoto, S, Cañas, X, Sakane, N, Yoshida, T, Saito, M
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1221719/
https://ncbi.nlm.nih.gov/pubmed/11256956
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