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Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7.
Stress-activated protein kinase 1 (SAPK1), also called c-Jun N-terminal kinase (JNK), becomes activated in vivo in response to pro-inflammatory cytokines or cellular stresses. Its full activation requires the phosphorylation of a threonine and a tyrosine residue in a Thr-Pro-Tyr motif, which can be...
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Main Authors: | , , , , , |
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Format: | Artigo |
Sprog: | Inglês |
Udgivet: |
2000
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Fag: | |
Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1221441/ https://ncbi.nlm.nih.gov/pubmed/11062067 |
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