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Diastereoisomeric analogues of gramicidin S: structure, biologicalactivity and interaction with lipid bilayers.

Analogues of a structurally equivalent version of theantimicrobial decameric cyclic peptide gramicidin S, GS10 [cyclo-(Val-Lys-Leu-d-Tyr-Pro)(2)], were designed to study theeffect of distortion in the beta-sheet/beta-turn structure of thecyclic peptide on its biological activity. In one approach, th...

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Main Authors: Jelokhani-Niaraki, M, Kondejewski, L H, Farmer, S W, Hancock, R E, Kay, C M, Hodges, R S
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2000
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1221201/
https://ncbi.nlm.nih.gov/pubmed/10903135
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