Molecular modelling and site-directed mutagenesis of the inositol 1,3,4,5-tetrakisphosphate-binding pleckstrin homology domain from the Ras GTPase-activating protein GAP1IP4BP.

GAP1(IP4BP) is a Ras GTPase-activating protein (GAP) that in vitro is regulated by the cytosolic second messenger inositol 1,3,4,5-tetrakisphosphate [Ins(1,3,4,5)P(4)]. We have studied Ins(1,3,4,5)P(4) binding to GAP1(IP4BP), and shown that the inositol phosphate specificity and binding affinity are...

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Main Authors: Cozier, G, Sessions, R, Bottomley, J R, Reynolds, J S, Cullen, P J
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1221154/
https://ncbi.nlm.nih.gov/pubmed/10861245
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