Differential recognition of snake venom proteins expressing specific Arg-Gly-Asp (RGD) sequence motifs by wild-type and variant integrin alphaIIbbeta3: further evidence for distinct sites of RGD ligand recognition exhibiting negative allostery.

Several studies have demonstrated that the amino acid residues flanking the Arg-Gly-Asp (RGD) sequence of high-affinity ligands modulate their specificity of interaction with integrin complexes. Because of the absence of structural data for integrin complexes with bound ligand, the molecular basis f...

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Detalhes bibliográficos
Main Authors: Rahman, S, Flynn, G, Aitken, A, Patel, Y, Hussain, F, Lu, X, Loftus, J C, French, D, Wijelath, E, Strand, K, Savidge, G F
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1220807/
https://ncbi.nlm.nih.gov/pubmed/10642531
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