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Methotrexate inhibits the first committed step of purine biosynthesis in mitogen-stimulated human T-lymphocytes: a metabolic basis for efficacy in rheumatoid arthritis?

The immunosuppressive and anti-inflammatory effects of low-dose methotrexate (MTX) have been related directly to inhibition of folate-dependent enzymes by polyglutamated derivatives, or indirectly to adenosine release and/or apoptosis and clonal deletion of activated peripheral blood lymphocytes in...

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Detalhes bibliográficos
Main Authors: Fairbanks, L D, Rückemann, K, Qiu, Y, Hawrylowicz, C M, Richards, D F, Swaminathan, R, Kirschbaum, B, Simmonds, H A
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1220447/
https://ncbi.nlm.nih.gov/pubmed/10432311
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