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Determinants of specificity for aflatoxin B1-8,9-epoxide in alpha-class glutathione S-transferases.

We have used homology modelling, based on the crystal structure of the human glutathione S-transferase (GST) A1-1, to obtain the three-dimensional structures of rat GSTA3 and rat GSTA5 subunits bound to S-aflatoxinyl-glutathione. The resulting models highlight two residues, at positions 208 and 108,...

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Autors principals: McDonagh, P D, Judah, D J, Hayes, J D, Lian, L Y, Neal, G E, Wolf, C R, Roberts, G C
Format: Artigo
Idioma:Inglês
Publicat: 1999
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1220132/
https://ncbi.nlm.nih.gov/pubmed/10085232
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