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The kinetics of acylation and deacylation of penicillin acylase from Escherichia coli ATCC 11105: evidence for lowered pKa values of groups near the catalytic centre.

Penicillin G acylase catalysed the hydrolysis of 4-nitrophenyl acetate with a kcat of 0.8 s-1 and a Km of 10 microM at pH 7.5 and 20 degreesC. Results from stopped-flow experiments fitted a dissociation constant of 0.16 mM for the Michaelis complex, formation of an acetyl enzyme with a rate constant...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Morillas, M, Goble, M L, Virden, R
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 1999
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC1220047/
https://ncbi.nlm.nih.gov/pubmed/9931321
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