Hydrogen bonding and protein perturbation in beta-lactam acyl-enzymes of Streptococcus pneumoniae penicillin-binding protein PBP2x.

A soluble form of Streptococcus pneumoniae PBP2x, a molecular target of penicillin and cephalosporin antibiotics, has been expressed and purified. IR difference spectra of PBP2x acylated with benzylpenicillin, cloxacillin, cephalothin and ceftriaxone have been measured. The difference spectra show t...

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Détails bibliographiques
Auteurs principaux: Chittock, R S, Ward, S, Wilkinson, A S, Caspers, P, Mensch, B, Page, M G, Wharton, C W
Format: Artigo
Langue:Inglês
Publié: 1999
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1220037/
https://ncbi.nlm.nih.gov/pubmed/9931311
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